TreatmentsSalmon DNA
Polynucleotide skin boosters that teach your skin to repair itself — hydration, elasticity, and glow rebuilt from within.
Curious about
Salmon DNA?
What is
Salmon DNA?
Salmon DNA therapy injects purified polynucleotides — DNA fragments extracted from salmon and refined to medical grade — into skin that's lost its bounce.
Rather than filling or freezing anything, the polynucleotides act as a repair signal: drawing in hydration, calming inflammation, and nudging fibroblasts to produce fresh collagen and elastin.
The change arrives the way real skin improvement does — gradually. Over a short series of sessions, texture refines, crepiness eases, and the skin starts catching light the way it used to — nowhere more visibly than the delicate under-eye area.
It's one of the most exciting regenerative tools in aesthetics right now, and our providers use it where it genuinely earns its place — thin, tired skin that filler can't fix.
Improves hydration, elasticity, and texture across the treated area — not just one spot.
Safe for the under-eye area, where crepey skin has few other good options.
Polynucleotides signal your own fibroblasts to rebuild collagen and elastin.
Three to four sessions a few weeks apart, with results compounding at each step.
When skin looks tired and filler isn’t the fix, regeneration is.
Skin quality is its own problem — separate from lines and volume. If the issue is texture, thinness, or dullness, no syringe of filler solves it. This is the tool that speaks that language.
Under-Eyes Look Crepey
Thin, finely-wrinkled skin below the eyes responds to repair, not volume.
Glow Has Gone Flat
Skin that stopped reflecting light well needs hydration and collagen, rebuilt from inside.
You Prefer Gradual and Subtle
Results build session by session — nobody will ask what you had done, only if you've been sleeping.
You're Already Investing in Skin
Layered with microneedling or lasers, polynucleotides amplify every other treatment's return.
Not covering
tired skin.
Teaching it
to recover.
Essentially, yes. The active ingredient is polynucleotides — purified DNA fragments derived from salmon, chosen because they're remarkably compatible with human skin and rigorously processed for safety.
Filler adds volume in a specific spot; salmon DNA improves the skin itself — hydration, elasticity, texture, and repair — across the whole treated area. One sculpts, the other regenerates.
Skin boosters work as a course: typically three to four sessions spaced a few weeks apart, then maintenance once or twice a year. Improvement builds gradually as the skin repairs.
The under-eye area is the star — fine crepey skin there responds beautifully — along with the face, neck, and hands. It's often layered with microneedling for compounding texture benefits.
The purification process removes the proteins responsible for fish allergies, and reactions are rare — but flag any allergy history at your consultation so your provider can review it properly before treating.
Where to next?
Related treatment
Microneedling
FDA-cleared Exceed collagen induction for smoother, firmer, clearer skin.
Explore the treatmentThe concern it treats
Dull, Dry or Tired Skin
Bring back hydration and glow
Start from the concernCommon question
What does Salmon DNA do for under eyes and skin quality?
Salmon DNA (polynucleotides) regenerates rather than fills. Under the eyes it thickens thin skin, improves hydration and microcirculation, and softens…
Read the answer
Repair, hydrate,
and glow again.
Medically reviewed by Barbara Kowalczyk, FNP‑BC and Michael Fressola, ACNP‑BC, board-certified nurse practitioners at Skin Med Spa. This page is for education and is not a substitute for a personalized medical consultation.