What does Salmon DNA do for under eyes and skin quality?
Medically reviewed by
The Skin Med Spa medical team, led by Barbara Kowalczyk, FNP-BC and Michael Fressola, ACNP-BC
Last reviewed: August 2026
Salmon DNA (polynucleotides) regenerates rather than fills. Under the eyes it thickens thin skin, improves hydration and microcirculation, and softens dark circles caused by tired skin. It does not fill deep hollows or erase true pigment.
Salmon DNA treatments use polynucleotides, purified DNA fragments derived from salmon that are biologically compatible with human skin. Injected in fine, shallow deposits, they act as a scaffold that activates fibroblasts, your collagen and elastin-producing cells, and improve blood flow and antioxidant defense in the tissue.
The under-eye area is where they shine, and understanding why is the key to good candidacy. The skin here is the thinnest on the face, which is why it looks tired and why volume-based fillers can look puffy. Polynucleotides suit it precisely because they strengthen and thicken the skin instead of adding volume. That improves dark circles that come from thin, crepey skin and softens fine lines.
What they honestly cannot do: fill a deep tear-trough hollow, which needs a different approach, and they do not treat brown pigmentation or vascular under-eye darkness.
Expect a course of 2 to 3 sessions, spaced 2 to 4 weeks apart, with the full result developing over 8 to 12 weeks and lasting 6 to 12 months. Downtime is minimal, with small bumps or mild redness for a day or two.
At Skin Med Spa, Salmon DNA is provided by our board-certified medical team at 960 Warren Ave. in Downers Grove, Illinois. Same-day appointments are available at 630-541-8413, and a consultation is the best way to find out what fits your skin and goals.
This is general information, not medical advice. Whether a treatment is right for you is determined by a licensed provider after an evaluation.